Non–β-Lactam Antibiotic Hypersensitivity Reactions

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Antibiotic hypersensitivity reactions and approaches to desensitization.

Before initiating antibiotic therapy, drug hypersensitivity is an important consideration, and a common strategy is to avoid giving patients medications when a high likelihood of severe reactions exists. With an increase in antibiotic resistance and a decrease in novel antibiotics, there is greater pressure to consider antibiotics in patients with a history of adverse reactions. The major conce...

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Hypersensitivity refers to undesirable (damaging, discomfort producing and sometimes fatal) reactions produced by the normal immune system. Hypersensitivity reactions require a pre-sensitized (immune) state of the host. Hypersensitivity reactions can be divided into four types: type I, type II, type III and type IV, based on the mechanisms involved and time taken for the reaction. Frequently, a...

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The Hypersensitivity Reactions

Para-aminosalicylic acid (P.A.S.) was first used in 1946 for the treatment of tuberculosis by I ehmann (1946). With the exception of nausea and vomiting, which Lehmann himself described, it was at that time thought that the drug was free from sideeffects. However, with its increasing use, reports of other toxic reactions began to appear (Nagley and Logg, 1949: Hemming and Stewart, 1949) and the...

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Hypersensitivity reactions to metronidazole.

BACKGROUND Hypersensitivity reactions to metronidazole are infrequently described. However, we believe that such reactions are increasing due to growing use of the drug for the treatment of amebiasis and anaerobe infections combined with other antibiotics. The present study assesses the need for oral provocation in patients with probable hypersensitivity reactions to metronidazole. METHODS We...

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The Hypersensitivity Reactions

Para-aminosalicylic acid (P.A.S.) was first used in 1946 for the treatment of tuberculosis by I ehmann (1946). With the exception of nausea and vomiting, which Lehmann himself described, it was at that time thought that the drug was free from sideeffects. However, with its increasing use, reports of other toxic reactions began to appear (Nagley and Logg, 1949: Hemming and Stewart, 1949) and the...

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ژورنال

عنوان ژورنال: Pediatrics

سال: 2020

ISSN: 0031-4005,1098-4275

DOI: 10.1542/peds.2020-023861y